FREQUENTLY ASKED QUESTIONS
F.A.Q.
If you don’t find the answers to your questions on this page, you can always write to us at: info@aqml.ca
General
Lyme Disease is a zoonotic, vector-borne illness caused by the bacterium Borrelia burgdorferi. For further information, please visit the Lyme Disease section of this website.
Lyme Disease has been a notifiable disease in Québec since 2003. Clinical doctors and laboratories are responsible for reporting cases to the public authorities. Between 2007 and 2020, 2091 confirmed (reported) or probable cases of Lyme Disease were registered in the MADO system. In 2022, 586 cases of Lyme disease were reported to public health authorities, including 527 confirmed or probable cases acquired in Quebec and 59 cases acquired outside Quebec or where the place of acquisition was unknown. However, according to experts at the U.S. Centers for Disease Control and Prevention (CDC), the actual number of cases of Lyme Disease is 6 to 12 times higher than the number of confirmed or probable cases.1 For further information on cases reported in Québec, please visit:
https://www.inspq.qc.ca/zoonoses/maladie-de-lyme/resultats-de-surveillance#surv_acarologique
1 Centers for Disease Control and Prevention. 2021. Lyme Disease: Data and Surveillance – How many people get Lyme disease? https://www.cdc.gov/lyme/stats/humancases.html MSSS. 2021
Ticks develop in three stages (larva, nymph, adult). Cases of Lyme Disease are generally acquired through the bite of Ixodes scapularis in the nymph stage. At this stage, ticks are so small (about the size of a poppy seed) that they usually go unnoticed , and therefore remain attached to the skin for longer. Adult ticks can also transmit the bacterium and are usually the size of a sesame seed.
Regions and environment
- Capitale Nationale
- Mauricie and Centre-du-Québec
- Estrie
- Montréal
- Outaouais
- Chaudière-Appalaches
- Laval
- Lanaudière
- Laurentides
- Montérégie
Blacklegged ticks are found in wet areas such as forests, woodlands, tall grass, gardens, fields, landscaping and piles of fallen leaves. Nature and gardening enthusiasts, as well as those who work in these environments, are all at risk of exposure to ticks.
Government of Quebec. 2021.
Lyme disease. https://www.quebec.ca/sante/problemes-de-sante/a-z/maladie-de-lyme/
INESSS. 2019. From diagnosis to treatment of localized and disseminated Lyme Disease. Report supporting clinical decision-making tools for diagnosis and treatment. Report written by Geneviève Morrow and Fatiha Karam. Québec, Qc: INESSS, p. 51 and 52/192.
Blacklegged ticks can be active at 4 °C and above, even in snowy conditions. The risk of contracting Lyme Disease after a tick bite exists all year round; in Québec, it is high in summer and low in winter.
INESSS. 2019. From diagnosis to treatment of localized and disseminated Lyme Disease. Report supporting clinical decision-making tools for diagnosis and treatment. Report written by Geneviève Morrow and Fatiha Karam. Québec, Qc: INESSS, p. 54/192. MAPAQ. 2021. Lyme Disease. https://www.mapaq.gouv.qc.ca/fr/Productions/santeanimale/maladies/transmissibleshumain/Pages/MaladieLyme.aspx
Co-infections
No. Several other disease-causing bacteria are present in the saliva of blacklegged ticks and can be transmitted to humans upon bite. As a result, Lyme Disease now tends to be referred to as “Lyme Disease and its co-infections.”
Nelder, MP. Russel, CB. Sheehan, NJ. Sander, B. Moore, S. Li, Y.
Johnson, S. Patel, S. Sider, D. 2016. Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review. Parasite Vectors. 5 (265): 14 p.
Symptoms
Treatments
Case studies
1. Quoi faire au stade localisé?
- Wear light-coloured pants and a long-sleeved shirt to spot ticks more easily.
- Tuck your sweater into your pants and the bottom of your pants into your socks.
- Wear closed shoes
- Use mosquito repellent containing DEET or icaridin on clothing and exposed skin (always follow label instructions)
- Wear permethrin-treated clothing (always follow label instructions)
- Walk on open trails or paths
- Make sure that children and pets stay on the trail.
- Avoid using trails created by animals (such as deer and moose), as ticks are often found in the grass and plants along these trails.
- Check for ticks:
- On yourself (Check for ticks all over your body (hair, armpits, inner thighs, navel, back of knees, etc.)
- Your pets
- Your clothes
- Your outdoor equipment, such as back packs.
- Take a shower or bath as soon as possible, as this can help you find ticks that haven’t yet latched on. If you’re not showering or bathing, check your whole body and that of your children for ticks.
- If you find a tick clinging to your skin, remove it as quickly as possible.
- To kill any loose ticks on your clothes, put dry clothes in a dryer on high heat for at least 10 minutes. If your clothes are damp, they may take longer to dry.
- If you wash your clothes, use hot water and dry at a high temperature. Ticks can survive a cold or lukewarm wash cycle.
- Immediately remove the tick using a tick remover (available at the pharmacy). If you don’t have your own, use fine-tipped tweezers. Make sure not to rotate the tick. Don’t crush the tick’s abdomen to avoid transmitting the bacteria present in the tick to the person bitten. Do not attempt to remove the tick using nail polish, petroleum jelly or heat;
- Wash the bite area with soap and water and disinfect the wound with an alcohol-based hand sanitizer;
- Store the tick in a sealed container and write the date of the bite. Ticks can be stored for up to 10 days in the refrigerator if alive, or in the freezer if dead;
- Make an appointment at a medical clinic as soon as possible;
- Bring the container to your medical appointment to help diagnose Lyme Disease;
- Watch for the appearance of erythema migrans (a sore that appears on your body and then disappears after a while).
If you were bitten and develop erythema migrans, it is important to consult a doctor as soon as possible. The latter should follow the recommendations of INESSS (2021): the presence of erythema migrans is sufficient to obtain a prescription for antibiotic treatment. In this case, it can be administered without a serological diagnosis of Lyme Disease. Here’s a simple table taken from the INESS document explaining the clinical approach to bites and erythema migrans.
*Please note that the INESSS document is a good reference, but the actual treatment choice remains at the clinician’s discretion.
The INESS also recommends monitoring the onset of symptoms (neurological, arthritic, cardiac, etc.) of the disease during the observation period, during and after treatment. The appearance of systemic symptoms may influence the choice of treatment. The patient is advised to use the following file: https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Biologie_medicale/Lyme_PPE/Lyme_Feuille-de-suivi.pdf
Please note the following points:
- Patients may take an antipyretic/analgesic (e.g. acetaminophen, ibuprofen) in conjunction with their antibiotic treatment to relieve pain and general systemic symptoms.
- A reaction called the Jarisch-Herxheimer reaction may occur following the start of antibiotic therapy. This systemic inflammatory reaction may occur during the treatment of spirochaete infections such as those caused by Borrelia burgdorferi.
Elle est généralement associée à la mort des bactéries. It is generally associated with the death of bacteria. However, it should not lead to discontinuation of the antibiotic, and you should notify a healthcare professional if in doubt.
*For tips on how to reduce this “Herx” reaction, you can rely on the AQML guide.
Erythema migrans are usually in the form of a target (red outline, white interior, approx. 5 cm in diameter). Its characteristics (size, shape and appearance) and its duration can vary considerably from one individual to another. Please note that certain sores caused by tick bites do not resemble classic erythema migrans. Smaller or atypical sores must be given the same attention as larger erythema migrans. The following illustrations will give you a better idea of what erythema migrans looks like.
Even if you’re not sure, we strongly recommend that you seek medical attention. The INESS guidelines suggest that if a patient has skin involvement without other manifestations suggestive of the disseminated́ stage, the physician should favour treatment covering both pathologies (e.g. cefuroxime axetil) if there is hesitation between the diagnosis of infectious cellulitis and erythema migrans.
Erythema migrans is one of the first signs of Lyme Disease, but is absent in 20% of cases, and often goes unnoticed. In Québec, post-exposure prophylaxis (PEP) is available for asymptomatic people recently bitten by a blacklegged tick to prevent Lyme Disease. According to INESSS, PEP is recommended when erythema migrans is not present and all the following criteria are met:
- The bite occurred in a geographical area covered by the application of the PPE
- The tick remained attached to the skin for a period of 24 hours or more
- The time between tick removal and initiation of PEP treatment is less than 72 hours
- If all these criteria are met, single-dose doxycycline PEP can be offered, in the absence of contraindications.
The geographical sectors covered by the application of the PPE are:
- Municipalities in the Estrie health and social services region;
- Municipalities in the Lanaudière health and social services region;
- Municipalities in the Montérégie health and social services region;
- Municipalities in the Outaouais health and social services region;
- Municipalities in the Montréal health and social services region;
- Municipalities in the Mauricie-et-du-Centre health and social services region of Québec
Here is a more comprehensive list provided by the MSSS: https://www.msss.gouv.qc.ca/professionnels/documents/maladie-lyme/liste-municipalites-PPE_Lyme-2023.pdf
For more information on the PPE, please refer to the following document:
https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Biologie_medicale/Lyme_PPE/Outil_aide_decision_PPE.pdf We also recommend that you keep track of your symptoms using this monitoring sheet:
Should symptoms suggestive of the disease appear, clinical evaluation is essential in order to initiate the appropriate treatment.
Our position: The AQML would like these criteria to be abolished, and for anyone bitten by a tick to be able to receive preventive treatment, regardless of the area of acquisition or length of exposure.
2. What to do in the disseminated stage?
- First of all, a good start is to complete Dr. Horrowitz’s questionnaire, which you’ll find under the Support Tools tab. This questionnaire is designed to help you assess your chances of developing the disseminated stage of the disease * Please note that it is not a diagnostic tool.
- Next, we recommend that you make an appointment with your doctor. At your medical appointment, we suggest that you bring a printed version of the questionnaire and emphasize your tick-bite history, as well as any symptoms you may have developed as a result. At this appointment, you can also ask to be tested for Lyme Disease.
3. Tests diagnostiques
Blood tests should be taken at a CLSC or hospital near you, after seeing a doctor. Samples will be sent to the diagnostic laboratories listed below for analysis.
Currently, the test recommended and approved by public authorities in Québec is the two-part serology test. The first part is a screening test (ELISA) and the second part is a confirmation test (Western blot).
1) The ELISA tests
The ELISA test is performed at two designated facilities in the province, CHU de Sherbrooke and Hôpital Charles-Le Moyne, and is used to test the immune response against the bacteria. If the result of this test is negative, the sample is considered to be negative for antibodies against B. burgdorferi and does not undergo further analysis.
Note that the proportion of false -negatives is high. (Please refer to the Diagnosis section to understand the key reasons for a negative test in a patient).
2) Western blot
If the ELISA results are positive or equivocal, the samples are forwarded to the National Microbiology Laboratory in Winnipeg, where the Western blot test is performed. This test consists of two separate analyses, one for immunoglobulin M (IgM) and the other for immunoglobulin G (IgG). Immunoglobulins are antibodies produced by the body to defend itself against bacteria (antigen). Again, a negative result can be obtained even if you have the disease.
- The test is done too soon after exposure (“bite”): Patients take a few weeks to develop antibodies to the disease.
- Patients suffering from the chronic form have a defective immune system: in this case, the patient’s immune system becomes so weak that antibodies are unlikely to be present.
- The antibodies are practically all attached to the antigens in what is known as an immune complex, leaving no free antibodies to be detected in the blood.
- There are almost 300 Borrelia subspecies. The tests cover only some of them, meaning that patients may be infected with a strain that has not yet been tested by the laboratory.
- The patient’s symptoms may be explained by co-infection rather than Borrelia infection. For example, tick-borne fever (TBRF) often creates symptoms similar to Lyme, which means patients will test negative, hence the importance of also checking for co-infections.
- The bacteria may not be present in the blood at the time of testing but hidden in other tissues.
- According to INESS, test sensitivity is low for Lyme Disease contracted in Europe, Asia and North Africa. This is mainly since the B. burgdorferi genospecies are different.
- If the disease was contracted on a different continent, it is important to mention it, as different immunoblot tests >will be used (differences in choice of antigens and positivity criteria).
- The tests include a wider range of testmethods. More specifically, the “panels” will involve a range of direct and indirect tests, making it possible not only to check the immune response, but also to look for the direct presence of pathogens in the blood.
- Tests detect the presence of a wider range of Borrelia strains.
- The tests also check for the presence of co-infections, which can sometimes explain the patient’s symptomatology.
- You should mention to your doctor that, according to data collected by the INESSS, a majority of patients diagnosed with Lyme Disease in Québec cannot remember being bitten by a tick or having erythema migrans. It’s therefore important not to rule out such a diagnosis when the clinical picture is compatible with Lyme Disease, and to carefully assess the risks of tick exposure in the past (for example, lifestyle, outdoor activities, places of residence and tourism, and contact with pets that go outdoors).
- First, check your symptoms by filling out Dr. Horowitz’s questionnaire. (Available in the Support Tools section.)
- Take the test results to your doctor to demonstrate your clinical and condition pictures.
- If you think you have Lyme Disease and your doctor is still sceptical about serological tests and your condition, we recommend that you change doctors until you find one who listens to your needs. If your process is difficult, you can always contact us. Si vos démarches sont difficiles, vous pouvez toujours nos consulter at info@aqml.ca.